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Formation of IAA was considered likely as a result of oxidase deamination of NMT (Barker et al., 1980), but was later proven being also in part by direct deamination by MAO (Barker et al., 1982). Pretreatment with the MAO-I iproniazid in rat whole brain homogenates inhibited IAA development by 83%, NMT and DMT-NO formation ended up inhibited by 90%
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